upload abstract| Wednesday .::. 04 June |  |
09:50 Opening [Branding]
10:00 Parallel Sessions A
Session 1: The hypothalamus-pituitary axis and nutrient metabolism [Patio]
Chair: Arie Nieuwenhuizen (Maastricht, Limburg)
Achim Peters (Luebeck, Germany) The Selfish Brain: HPA-axis and the origin of obesity (30')
Christian Hubold (Luebeck, Germany) Analysis of the central glucocorticoid feedback in patients with obesity, diabetes, and depression (15')
Femke Rutters (Maastricht) Hyperactivity of the Hypothalamus/Pituitary/Adrenal axis is related to dietary restraint in normal weight women (15')
Anneke van Vught (Maastricht) Effects of soyprotein alone or as part of a meal on the somatotropic axis (15')
Session 2: Nuclear receptors and metabolism [Renkum]
Chair: Eric Kalkhoven (Utrecht)
Mark Gurnell (Cambridge, United Kingdom) Targeting PPARγ in the metabolic syndrome – novel insights from human genetic studies (30')
Saskia van Mil (Utrecht) Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy (15')
Andries Gilde (Maastricht) Differences between PPARα and PPARδ in cardiac transcriptional regulation (15')
Anastasia Georgiadi (Wageningen) Role of PPARs in fatty acid dependent gene regulation in the mouse heart: a transcriptomics approach (15')
Maaike Oosterveer (Groningen) Lxrα deficiency hampers the hepatic adaptive response to fasting in mice (15')
Session 3: The blood-brain-barrier: functional roles and therapeutic targeting [Gelderland]
Chairs: Eleonora Aronica (Amsterdam) & Govert Hoogland (Maastricht)
Alon Friedman (Beer-Sheva, Israel) The Role of the blood-brain barrier in epileptogenesis (45')
Ralph Clinckers (Brussel, Belgium) Cerebral uptake of drugs and pharmacoresistance in epilepsy (15')
Olaf van Tellingen (Amsterdam) Brain tumors and the blood-brain barrier (15')
Machteld Vellinga (Amsterdam) MR imaging of the blood-brain barrier (15')
Session 4: What happens when the amygdala rules [Branding]
Chairs: Judith Homberg (Nijmegen) & Heidi Lesscher (Utrecht)
Hannah Clarke (Cambridge, United Kingdom) Serotonergic modulation of prefrontal-subcortical interactions (30')
Heidi Lesscher (Utrecht) Amygdala control of anxiety and alcoholism (15')
Daan Baas (Utrecht) The role of amygdala abnormalities in schizophrenia and paranoia (15')
Roshan Cools (Nijmegen) Serotoninergic regulation of behavioural and emotional control processes (15')
Guido van Wingen (Nijmegen) Neural state and trait correlates of mood-incongruent memory formation and retrieval in first-episode major depression (15')
Session 5: Mapping gene regulatory networks in the nervous system [Doorwerth]
Chair: Ronald van Kesteren (Amsterdam)
Roshan Kumar (Cambridge, MA, USA) Unraveling the transcriptional regulatory circuitry governing pluripotency and differentiation (45')
Onno Meijer (Leiden) Integration of stress signals in the brain: modulation of the CRH gene by nuclear receptor coregulators (15')
Marten Smidt (Utrecht) Molecular programming of mesodiencephalic dopaminergic neurons (15')
Harold Mac Gillavry (Amsterdam) Transcriptional regulation of successful neuronal regeneration (15')
11:30 Coffee Break
12:00 Plenary Session [Branding]
Session 6: ENP Plenary Lecture I
Chair: Marian Joëls (Amsterdam)
Stafford Lightman (Bristol, United Kingdom) The importance of rapid time domains in HPA function
12:45 Lunch
14:00 Parallel Sessions B
Session 7: Feedback to the brain: new perspectives in childhood obesity? [Patio]
Chair: Felix Kreier (Amsterdam)
Per Södersten (Stockholm, Sweden) A framework for the treatment of obesity (30')
Arine Vlieger (Nieuwegein) Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomised controlled trial (20')
Hiltje Oude Luttikhuis (Groningen) Parental Perceptions on their young child’s weight (20')
Nitash Zwaveling-Soonawala (Amsterdam) Childhood obesity; the mandometer as a promising new treatment modality (20')
Session 8: Mineralocorticoid receptor action on adipose tissue: clinical relevance [Gelderland]
Chair: Roel de Rijk (Leiden)
Maria-Christina Zennaro (Paris, France) The pivotal role of the mineralocorticoid receptor in adipogenesis (45')
Yanina Revsin (Leiden) Reversible effects of glucocorticoids excess on the hippocampus of type 1 diabetic mice (15')
Alberto Pereira (Leiden) Clinical and molecular manifestations of irreversible effects of glucocorticoid excess (15')
R. Angela Sarabdjitsingh (Leiden) The dynamic control of MR and GR in the rat hippocampus by corticosteroids (15')
Session 9: Master's Students [Renkum]
Sandra Cornelisse (Amsterdam) The influence of maternal care on the morphology of the adult rat hippocampus (15')
Sybrenne Lenstra (Groningen) The effect of NKx6.2 expression on in-vitro differentiation of neural stem cells into oligodendrocytes (15')
Annika Lüttjohann (Nijmegen) Racine scale for PTZ-induced seizures revised (15')
A.J. Boender (Nijmegen) The molecular basis of experience-dependent plasticity in the rat barrel cortex (15')
Vera van Dis (Rotterdam) Neuronal degeneration in SOD1-ALS mice facilitates aggregate formation in surrounding astrocytes (15')
Marianne van Leeuwen (Utrecht) Involvement of central CRF functioning in affective startle modulation (15')
Session 10: Developmental aspects of serotonin signaling [Doorwerth]
Chairs: Marten Smidt (Utrecht) & Hans van Hooft (Amsterdam)
Patricia Gaspar (Paris, France) The multiple tricks of serotonin in thalamocortical development (30')
Harry Uylings (Amsterdam) The late embryonal and postnatal development of the human cortex (20')
Hans van Hooft (Amsterdam) The role of reelin in postnatal maturation of the cortex: is a bigger brain better? (20')
Marten Smidt (Utrecht) Modulation of serotonin transporter function during fetal development, cause dilated heart cardiomyopathy and lifelong behavioral abnomalities (20')
Session 11: Dynamic neuron–glia interactions in health and disease [Branding]
Chairs: Anne-Marie van Dam & Huib Mansvelder (Amsterdam)
Michal Schwartz (Rehovot, Israel) Immunity to self and self-maintenance: involvement in brain plasticity in health and disease (45')
Knut Biber (Groningen) Chemokines in neuron-microglia signaling (15')
Mark Verheijen (Amsterdam) Sterol responsive element binding proteins (SREBP) are essential for proper myelination of peripheral nerve by regulating Schwann cell lipid synthesis (15')
Miriam van Strien (Amsterdam) Tissue Transglutaminase in oligodendrocyte precursor cells: a role in myelination? (15')
15:30 Poster Session 1 (+ coffee break) [Fitness]
Endocrinology / Molecular & Cellular Neuroscience
17:00 Parallel Sessions C
Session 12: Insulin/IGF-1 signal transduction and life span control [Renkum]
Chairs: Hanno Pijl & Rudi Westendorp (Leiden)
Martin Holzenberger (Paris, France) Hypothalamic control of GH/IGF-1axis activity in the regulation of life history (30')
Jan Hoeijmakers (Rotterdam) DNA damage and repair: from premature aging to the somatotrophic axis and longevity (20')
Rudi Westendorp (Leiden) GH/IGF-1 axis in longevity (20')
Hermine van Duyvenvoorde (Leiden) Phenotypic features of mutations in the GH/IGF-I axis (20')
Session 13: Cortisol awakening rise: mechanism and implications [Gelderland]
Chair: Roel de Rijk (Leiden)
Stefan Wüst (Trier, Germany) Methodology and relevance of the cortisol awakening response (45')
Nienke van Leeuwen (Leiden) Mineralocorticoid receptor (MR) gene variants modulate the CAR (15')
Sophie Vreeburg (Amsterdam) HPA-axis function and depression: first results from the Netherlands Study of Depression and Anxiety (NESDA) (15')
Gerthe Veen (Leiden) Dimensional versus categorical approach to phenotyping in relation to HPA-axis measures in patients with mood and anxiety disorders (15')
Session 14: Synaptogenesis: molecules and mechanisms [Branding]
Chair: Gerard Borst (Rotterdam)
Adrian Rodriguez-Contreras (Rotterdam) New vistas of the development of the calyx of Held synapse (15')
Christian Lohmann (Martinsried, Germany) Imaging structural and functional plasticity during synaptic partner selection (15')
Joris de Wit (La Jolla, USA) Two cargo-specific fusion modes for secretory granule exocytosis in cortical neurons (15')
Noam Ziv (Haifa, Israel) Maintaining the CNS synapse: Insights from live imaging experiments (45')
Session 15: Immunology and epilepsy: etiologic factors and challenges in treatment [Patio]
Chairs: Marian Majoie (Maastricht) & Willy Renier (Nijmegen)
Marian Majoie (Maastricht) Immunology and epilepsy: etiologic factors and challenges in treatment (30')
Tamara Martha (Maastricht) Neurodegenerative aspects of seizures (15')
Karin Boer (Amsterdam) Innate immunity in temporal lobe epilepsy and epilepsy- associated malformations of cortical development (15')
Kim Rijkers (Maastricht) Vagus nerve stimulation & neuro-immune modulation in epilepsy (15')
Willy Renier (Nijmegen) Clinical value of intravenous immunoglobulin (IVIg) therapy in refractory epilepsy (15')
Session 16: New kids on the block: microRNAs [Doorwerth]
Chair: Erno Vreugdenhil (Leiden)
Gerhard Schratt (Heidelberg, Germany) MicroRNAs and synaptic plasticity (45')
Eugene Berezikov (Utrecht) Expression profiling and discovery of microRNAs in human and macaque brain (15')
Joris Pothof (Rotterdam) MicroRNAs in mammalian aging (15')
Erno Vreugdenhil (Leiden) Tissue specific microRNAs affects glucocorticoid receptor activity (15')
19:00 Dinner
21:00 Plenary Session [Branding]
Session 17: Hersenstichting Lecture
Chair: Knut Biber (Groningen)
Kazuhide Inoue (Fukuoka, Japan) Neurons talk with microglia through nucleotides